Vegan With Blood Pressure That Is Too Low (Causes and Fixes)

One of the benefits of being a vegan is that your blood pressure is likely to decrease by a lot. Naturally, when you eat a plant-based diet, your calorie intake will usually decrease without you even thinking about it, and so will your waistline.

When blood pressure is low but you have no symptoms associated with it, this can be a very good thing. In fact, you’re more likely to live longer than average due to the fact that cardiovascular disease is one of the biggest causes of death in middle and old age.

When I started to eat a healthy diet (containing mostly plant foods) my blood pressure decreased to about 90/60. This is very low and comparable to the blood pressure of 10-year old.

What normally happens is your body will adapt and you will not develop symptoms from having blood pressure as low as this. While some people will develop a problem called “orthostatic hypotension”.

Orthostatic hypotension is a problem when you’re sitting or lying down and then you get up and start feeling light-headed and dizzy – even fainting in severe cases!

Sometimes medications are the cause of orthostatic hypotension, but it may also be due to blood loss, anemia, and even supplements.

The signs of low blood pressure

Here are some of the main symptoms associated with having too low blood pressure.

  • Dizziness
  • Feeling lightheaded
  • Feeling dizzy and faint when getting up from a seated or lying position
  • Blurred vision
  • Nausea
  • Lack of energy
  • Fantaing

Low blood pressure falls into the range of 90/60 and below. Whereas normal blood pressure is between 90/60 to 120/80.

Studies show that heart disease risk can start increasing after your systolic blood pressure increases beyond 115. Anything below this isn’t likely to significantly decrease your risk of heart disease.

It’s quite common for people on calorie restriction or a low-calorie vegan diet to have blood pressure readings as low as 90/60 to 100/60.

Most people who maintain a blood pressure between these ranges will not show any negative symptoms, but if you are, then there could be a few causes, and not always just because of blood pressure.

Therefore it’s crucial that you get evaluated by a doctor to find out the reason for your symptoms and if there is any medical condition which is causing the dysregulation of blood pressure.

How to deal with blood pressure that is too low on a vegan diet

Assuming the doctor has given you the “all clear” and you’re a healthy bunny, then there are some ways that you can increase your blood pressure.

1. Increase calorie intake

A low-calorie diet is very effective in reducing blood pressure to very low levels. One way to help you increase your blood pressure reading is by simply eating more calories. Aim to increase your body weight a little by increasing calorically dense foods in your diet.

See my article on how to gain weight as a vegan and how to not lose weight for further information.

2. Increase salt intake

This isn’t something that is often recommended because most people have the opposite problem and are trying to lower blood pressure.

In your case, since you’re suffering from symptoms related to low blood pressure, increasing salt in your diet can be helpful. Perhaps you can try adding a bit of sea salt to your meals.

3. Decrease potassium-rich foods

Check out the amount of potassium you’re consuming in your diet by using tools such as CRON-O-METER.

If you’re eating a plant-based or raw food diet, you’re likely getting a large amount of potassium and this can sometimes cause problems, especially if salt intake is low as well.

4. Increase caffeine intake

If you enjoy a cup of coffee, then why not add it back to your diet. Coffee is not as bad as people make it out to be! Studies show that coffee may actually be beneficial for health when consumed moderately.

One thing to remember when it comes to drinking coffee though is to stop drinking at least 6 hours before bedtime. Drinking caffeinated drinks at night can cause sleep loss and poor quality sleep, even if you don’t think you were affected.

See my article on caffeine at bedtime.

5. Try licorice tea or take licorice supplements

Licorice is well known to increase blood pressure significantly when consumed in large amounts as candy or taken as a supplement.

Studies have shown that glycyrrhizin taken daily for four weeks is able to increase systolic blood pressure by 14.4 mm/Hg.

When using licorice to increase blood pressure, make sure that you are monitoring your blood pressure.

Licorice can be healthy in moderate amounts. However, men should be aware that large amounts of licorice can significantly decrease total testosterone.

These effects disappear within a few days after discontinuing the supplement.

6. Try bitter orange to raise blood pressure

Bitter orange supplements are used to help suppress appetite, improve digestion, but they can also cause blood pressure to increase.

There have been warnings about people who are at risk of high blood pressure to avoid bitter orange supplements.

You could this supplement to see what effects it has on blood pressure.

Once again, carefully monitor blood pressure and speak with your doctor, especially if you’re taking any medications.

7. Increase fluid intake

Dehydration can cause low blood pressure and can easily be solved by simply increasing fluid intake during the day.

Do you often find that your symptoms are worse during the summer? Perhaps this is because you’re becoming dehydrated.

Although plant-based foods contain a lot of water content, you should also regularly consume water, tea and other liquids (non-alcoholic) to remain hydrated during the day.

8. Support adrenal function

The adrenal glands are important in helping regulate blood pressure. Due to stress and other factors, adrenals can become fatigued.

Increase intake of Vitamin C, Magnesium, B5, B6, and B12.

Other supplements which may be useful for supporting adrenal function are licorice root, ginseng, ashwagandha and maca root.

Identify and reduce the intake of foods that lower your blood pressure too much

You don’t have to go crazy here and start removing everything from your diet, but it might be worth taking a look at your diet to see if you’re consuming too much of something which may be lowering your blood pressure.

We already know that a vegan diet is very effective at lowering blood pressure, so here’s a list of foods to watch out for:

  • Garlic and onions
  • Dark chocolate
  • Bananas
  • Red Beets
  • Leafy greens (spinach, kale, romaine lettuce etc).

Again, to make it clear: I’m not recommending that you completely remove these foods from your diet, but if you’re drinking lots of green smoothies or highly concentrated juice, then perhaps aim for more variety instead.

Check your supplement stack

Supplements can be very useful in lowering blood pressure, but if your blood pressure is already low, then it may cause some issues.

There are countless supplements out there so it’s difficult to name them all, but do some research on the supplements you’re taking and see if you can identify one that might be contributing to the problem.

Conclusion

Maintaining a healthy low blood pressure can be a very positive thing for your health as long as you aren’t suffering any symptoms associated with it.

Sometimes there are things you can identify that are causing the problem, but not always.

If you’re on a vegan diet and your blood pressure is too low, try the things I mentioned above to see if it helps resolve your issue.

However, if you haven’t seen a doctor already, I highly recommend you get some basic blood tests done to check for any issues.

How Much Bilberry Should I Take Daily For Health Benefits?

bilberry plant contains anthocyanins

Bilberries are an amazing antioxidant-rich food which can ward off many diseases if recent studies are to be believed. The anthocyanins in bilberries are responsible for much of their benefits, but if you don’t fancy bilberries, there are bilberry supplements available which also do the trick!

You probably guessed it already, but bilberries are a cousin of blueberries. They are quite similar, but some people don’t like the bitter taste of bilberries.

And that’s a shame because bilberries are often higher in antioxidants than blueberries. One way to consume them is to make a jam, but these often come with heaps of sugar.

One simple way for those poor unfortunate souls who don’t find the taste of bilberries all that pleasurable is to take a supplement which contains a high concentration of these anthocyanins.

But the question is: how much bilberry should you take to get the health benefits?

Many studies have been done on bilberry fruit consumption and bilberry extract. It’s recommended that you take between 160-480 mg of bilberry extract.

Read below to see the main benefits of bilberries and the doses used in studies!

Health benefits of bilberry

There’s been a lot of research over the last few decades on bilberry consumption and also bilberry supplements in both animals and humans.

I’ll go through some of the main benefits associated with consumption bilberries either as a food or supplement and then summarize the dose or amount you need to enjoy the health benefits.

Although dosing and its effects in humans are scarce, there is some data available.

The health benefits of bilberries can be attributed to the biological activity of anthocyanins where they alter gene expression, improve DNA repair, modulate cell-signaling pathways and provide antiglycemic and antimicrobial effects.

Vision

As mentioned in one of my previous articles, bilberries are one of the best eye supplements you can take to improve your vision and protect your eye health.

Anecdotal evidence back at the time of world war 2 emerged when pilots noticed an improvement in their night vision. Later on, these reports inspired researchers to look at the effect of bilberries on vision in animals and humans.

Studies have shown bilberry can help with:

  • Reducing free radical damage, cell death and inflammation in the eye when the eyes are exposed to blue light. [1]
  • Boost intracellular antioxidant enzymes in the eye to prevent free radical damage.
  • Improve retinal vascular health.
  • Prevent diabetic retinopathy.
  • Improve visual function in patients with glaucoma when combined with Ginkgo Biloba.
  • Prevent eye fatigue
  • Improve dry eye syndrome

The anthocyanins in bilberries also can indirectly improve vision by reducing blood sugar, improving blood pressure, reducing cholesterol and improving blood flow.

In one study, subjects who were experiencing eye fatigue took 480 mg of bilberry extract and saw improvements in eye pain, eye heaviness, uncomfortable sensations and foreign body sensations. [2]

Web MD suggests a dose of 160 mg taken twice daily for people with retinal diseases. [3]

And finally, in another randomized, double-blind, placebo-controlled trial, an extract called Mirtoslect which contains highly purified anthocyanin extract was used to treat dry eyes in rats and showed that it was effective in improving the antioxidant status and tear secretion.

Reduces blood sugar

It’s often advised that people who are diabetic or have high blood sugar avoid fruits. However, berries are one type of fruit that is low glycemic and actually improve blood sugar levels when consumed with a high carbohydrate and high-fat meal.

In a study in young healthy volunteers, bilberry drink with oatmeal decreased the blood sugar spike after the meal. [4]

Another study using a single supplement of standardized bilberry extract with 36% wet weight (w/w) anthocyanins (each capsule was 470 mg of bilberry extract) or equivalent to 50 grams of bilberries.

The use of bilberry extract significantly reduced postprandial glucose and insulin and demonstrates that this may be useful in people who have high blood sugar levels or diabetics. [5]

Protect against cardiovascular disease

Bilberries have also been recognized to have benefits for the cardiovascular system because it strengthens blood vessels, has powerful antioxidant and anti-inflammatory effects and also improves cholesterol profile.

In 2016, researchers looked at the effects of bilberry consumption on risk factors for cardiovascular disease. Men and women consumed 150 grams of frozen stores bilberries 3 times per week for 6 weeks.

Consumption of bilberries led to a decrease in total cholesterol, triglycerides, glucose, and increased HDL cholesterol.

By showing significant improvements in LDL-C/TG ratio and increasing HDL cholesterol, this study confirms the benefits of bilberries in preventing cardiovascular disease. [6]

Improves and protects skin

Bilberries, due to their high amount of antioxidants are able to help prevent oxidative damage and UV damage to the skin. Studies have also shown that bilberries can regulate the immune system response in the skin and control inflammatory skin conditions such as atopic dermatitis. [7]

Other benefits

Those are some of the main benefits of taking a bilberry supplement or consuming them regularly as part of your diet. But there are a few other benefits that also have been shown, but mostly in animal studies.

  • Improvement in chronic fatigue syndrome
  • Prevention of urinary tract infections
  • Skin infections
  • Gastrointestinal disorders including IBD, celiac disease, with an improvement of symptoms like pain, bloating and diarrhea

How much bilberry should you take?

Depending on your reason for consuming bilberries or taking a supplement, the dose can vary. It’s recommended that you consume between at least 20-60 grams of dried bilberries daily or take a supplement that has been 160 – 480 mg of high concentration bilberry extract powder.

If you’re on any medications, then you may want to talk to your doctor about taking a bilberry supplement. Medications which may interact with bilberry supplements include medications for diabetes and blood clotting medications.

There is no advice available on dosing if you are pregnant. Therefore it’s recommended that you avoid high dose bilberry supplements.

Side effects

Bilberry fruit is considered very safe. Some studies have used supplements which contain bilberry, such as pycnogenol, and have been given for over 6 months. Of course, if you think you are having side effects from taking a bilberry supplement, speak with your doctor and discontinue for the mean time.

Best Sulforaphane Supplement

baby broccoli sprouts are high in sulforaphane

Sulforaphane is an organosulfur compound found in high concentrations in broccoli sprouts and other cruciferous vegetables, but also available as a supplement. If there was one compound that you should aim to get more of it would be sulforaphane. Intake of cruciferous vegetables high in this compound has been consistently shown to be beneficial for human health.

When I first started eating cruciferous vegetables, I wasn’t really a fan. In fact, I had to get used to the taste, which took me a few days. But eventually I made it through and broccoli became one of my favorite foods to eat and a staple in my diet.

We all know that vegetables are good for us, but so many people avoid eating them. This is really unfortunate as they offer many health benefits. One of the reasons people often give for avoiding cruciferous vegetables is the taste. Taking a supplement is one way around it.

There are many supplements to choose from, but only a few provide a decent amount of sulforaphane. The best sulforaphane supplements are the ones which contain active myrosinase.

There are cheap options like Jarrow Formula – Brocco Max which provides myrosinase and would be a great choice if you want quality but you’re on a budget. While other more expensive options are also available and have been used in clinical studies. (Scroll down for more details).

Below are 4 high-quality sulforaphane supplements


Now let’s have a look how this compound works to improve health and protect against disease! 🙂

How does sulforaphane work to improve health?

There are many ways that sulforaphane is able to protect against disease. It’s known for its ability to boost antioxidant protection, reduce inflammation, and remove harmful substances from the body.

Sulforaphane is a potent activator of the NRF2 pathway and this is one of the reasons behind its amazing health benefits. Many animal studies and population studies in humans have been conducted over the years on vegetable intake and the risk of common diseases like heart disease and cancer.

One thing that keeps popping up in these studies as a significant factor in the development of cancer is how often people eat cruciferous vegetables.

How many servings of cruciferous vegetables do you need to eat per week to decrease the risk?

According to some studies, just three to five servings per week can reduce the risk of cancer by 30-40%. [2] Consuming broccoli sprouts would get you most sulforaphane due to its high amount of glucosinolates like glucoraphanin.

Sulforaphane works in many ways to protect against cancer

  • It’s is a potent inducer of phase II enzymes – responsible for enhancing the excretion of harmful carcinogens in the body which can lead to cancer. [1]. Sulforaphane is also a potent activator of glutathione S-transferase and increases intracellular glutathione activity in human cells.
  • It inhibits phase I enzymes – These P450 enzymes are responsible for the activation of pro-carcinogens and cause cancer.
  • Encourages death of cancer cells – It increases the expression of pro-apoptotic genes involved in cell death while leaving healthy cells alone.
  • Blocks inflammation –  It suppresses and blocks the activation of transcription factors such as NF-Kappa B which is a key regular in inflammation and the encouragement of cancer cell growth.
  • Restores immune function – Studies show that it’s able to boost natural killer cells and restore immune function which has declined because of aging. The ability of the immune system to detect and kill cancer cells is crucial for cancer protection.
  • Inhibit blood vessel growth – The compound may inhibit or reduce the growth of blood vessels which feed tumors.

There are also many other benefits of sulforaphane!

  • Anti-viral – It’s shown to have antiviral activity against many viruses including HPV, influenza, Epstein-bar virus and hepatitis virus.
  • Anti-bacterial – It can inhibit the growth of certain types of bacteria like Mycobacterium and H.Pylori
  • Autism – In a study using sulforaphane, researchers observed an improvement in behavioral symptoms associated with autism. The improvement was significant with 54% having a significant reduction in abnormal behavior, 46% had improved social interaction, and 42% had improvements in verbal communication. Sulforaphane has also been shown to reduce levels of oxidative stress, inflammation and other markers associated with the condition. [3]
  • Cholesterol benefits –  Reduces LDL cholesterol and increase HDL cholesterol. Although protects LDL against oxidation.
  • Anti-glycation – Reduces advanced glycation end products (AGEs) which are responsible for hardening of the arteries, kidney disease, diabetes, skin aging and more.
  • Neurodegenerative disease – It has the ability to induce the expression of heat shock proteins which may help reduce the incidence of Parkinson’s disease and Alzheimer’s disease

These are just some of the amazing health benefits, but there are many more! Cruciferous vegetables also provide other compounds such as I3C and DIM that are also important in the benefits of broccoli, kale, sprouts and other vegetables in this family.

After you finish here, check out this video for more benefits.

How to choose the best sulforaphane supplement?

There are many different supplements available which promise to deliver a large amount of sulforaphane, but the amount of sulforaphane you get can vary wildly. This is not only dependent on how the supplement was formulated but also depends on the person taking the supplement.

Some supplements use mature broccoli extract, which has the least amount of sulforaphane, while other popular supplements are using broccoli seed extract (Jarrow) or broccoli sprouts.

To get the most sulforaphane, you want to choose a supplement which uses part of the plant which at most is days old. Pharmaceutical grade broccoli seed extract supplement tends to be a lot more expensive, provide a much higher amount of sulforaphane, and are also the ones used in clinical trials.

What if you wanted to get sulforaphane from food? 

According to Dr. Rhonda Patrick (video above), the amount of sulforaphane you would get from every 1 gram of fresh broccoli sprout would be around 2.4 micromole (0.425 mg). So in order to get between 40 to 60 mg of sulforaphane, you’d have to eat between 100 – 140 grams of broccoli sprouts.

For comparison, each serving of Avmacol Broccoli extract blend has 44 micromoles.

One way to get the most out of cheaper broccoli powder supplements which don’t contain active myrosinase is to take a broccoli sprout extract powder supplement and eat broccoli sprouts which contain the enzyme. This way the sprouts which contain the myrosinase can hydrolyze glucoraphanin from the supplement.

If this is manageable for you, then go with eating fresh broccoli sprouts, if not, check out some of the supplements below.

#1. Avmacol Sulforaphane Supplement – Used in the US and International clinical trials

If you want to one of the best and highest quality sulforaphane supplements, then it’d be a good idea to go for pharmaceutical grade or supplements used in clinical trials. And that’s exactly what Avmacol supplement provides you.

It contains 350 mg of its proprietary broccoli extract blend which contains over 25 mg of glucoraphanin and also active myrosinase.

Avmacol products have been validated by human tested with the detection of sulforaphane metabolites in the urine. They measured an average sulforaphane product of 44 micromoles of sulforaphane per serving. This varies due to differences in gut bacteria and metabolism.

See more details here.


#2. Onco Plus Max – Concentrated Brocco Raphanin from Broccoli Seed Extract – Pharmaceutical Grade

Each 500 mg of BroccoRaphanin capsule contains a standardized extract which contains 10% sulforaphane. To get the equivalent amount of from your diet, you would need to consume 100 grams of fresh broccoli sprouts.

This sulforaphane supplement was created from a proprietary form of broccoli seed which was grown and processed in the United States. Using very clean and non-toxic extraction methods (supercritical CO2 extraction).

Compared with many other supplements available Onco Plus Max contains one of the highest doses of glucoraphanin.

See more details here.


#3. Jarrow Formula – Brocco Max Capsules containing 30 mg of sulforaphane glucosinolate

A proprietary blend which contains myrosinase enzyme which is needed to convert glucosinolates into sulforaphane.

Tests have shown that BroccoMax yields at least 8 mg of pure sulforaphane potential per capsule, which is considerably higher than many other supplements available.

The process by which the supplement is manufactured is also standardized to deliver the highest purity and quality, and the ingredients are encapsulated for delayed release. This ensures that you get the maximum amount of sulforaphane possible.

The addition of calcium ascorbate in the supplement also facilitates the conversion of glucoraphanin into sulforaphane when it reaches the intestine.

Compared to other sulforaphane supplements, this one is relatively cheap and provides a significant amount of sulforaphane per dose.

See more details here.

How To Cure H Pylori Without Antibiotics

H Pylori is a difficult infection to treat with conventional antibiotics because of problems with resistance. Some people have to use a triple-therapy or a quadruple therapy which involves antibiotics and medications to reduce stomach acid. And even then cure rates might only be around as high as eighty-four percent.

Not only does the infection cause very uncomfortable symptoms, it can also raise the risk of stomach cancer if not treated and eliminated.

The main symptoms associated with H. Pylori include:

  • Loss of appetite – You don’t feel hungry and when you do, you feel full quickly.
  • Stomach pressure – Under your rib (left side) you may notice stomach pressure.
  • Nausea – Stomach inflammation can lead to symptoms of nausea.
  • Acid Reflux – You may have symptoms like burning and hoarse voice from this symptom.
  • Weight loss – Due to a decreased appetite, you will likely experience some weight loss.

Antibiotics are life-saving for millions of people and thankfully are still quite effective for many common bacterial infections. Although time may be running out as problems with resistance increase with continued use.

So when antibiotics start to fail, we have to turn elsewhere because the introduction of new and effective antibiotics into the market is painfully slow.

Now scientists are taking inspiration from nature and looking at plant-compounds to see if they are able to enhance the antibacterial effect, reverse resistance, or give insight into new approaches to develop synthetic and more potent versions.

In some cases, natural remedies derived from plants and mushrooms may even be effective by themselves at eradicating infections. However, one thing that is often overlooked by many people who advocate natural therapies is how the body processes and metabolizes these plant compounds.

The fact is that many plant compounds which display significantly antibacterial effects in the lab in a petri dish, may not necessarily live up to the same hype when you consume them. The tissue concentrations of these compounds can be too low.

However, when we’re talking about trying to eradicate an infection internally, say in the stomach, then natural treatments could be a more viable option. This is why a lot of research has been done on using natural treatments for H pylori and some have shown some success.

Disclaimer: These natural treatments recommended here are compiled from scientific research, my own experience in curing gastritis caused by h pylori, and feedback I’ve received from others. Be sure to consult with your doctor if you opt for natural treatments!

H Pylori Natural Treatment Regimen

As I already mentioned, there have been a few studies looking at natural cures for h pylori which don’t require antibiotics.

In some cases, these foods and supplements may be complementary and enhance antibiotics ability to eradicate the bacteria.

Combining several of them together may also give you more success. This is what I did to eliminate chronic gastritis I was experiencing in 2007.

Sulforaphane-rich Broccoli Sprouts

I don’t know about you, but I already loved broccoli sprouts, although they were difficult to get at the local supermarket. But if you have them where you live, then definitely pick some up!

One randomized controlled study in 50 humans who tested positive for H Pylori showed that eating 70 grams of 3-day-old germinated broccoli sprouts can inhibit gastritis caused by H pylori.

Sulforaphane found in broccoli sprouts seems to work in two ways: through a direct antibacterial effect and by increasing Nrf2 – a major antioxidant enzyme which leads to a decrease in reactive oxygen species and prevents damage to the stomach wall.

Consumption of broccoli sprouts lead to a decrease in urease measured by a urea breath test and also H. pylori stool antigen test. Biomarkers of stomach inflammation were also decreased in the broccoli group but not the placebo.

So although sulforaphane did not eradicate the infection fully, it did significantly reduce the number of bacteria and gastric inflammation and therefore could be a valuable tool-set in fighting h pylori. [1]

Garlic (Allicin)

If you ask someone to come up with a natural antibiotic, it’s more than likely that garlic will be on the list. Well, if you read my blog, you’ll know that I am a fan of allicin and I take it every day. I shared my previous success in curing an infection I had by combining it with an antibiotic.

In a study from 2001, researchers looked at the effect of beta-carotene, ascorbic acid, and allicin in eradicating H.pylro, then compared it with the standard protocol which was two antibiotics and a proton pump inhibitor.

Standard protocol – 66% eradication

Allicin (4200 mcg) + standard protocol – 90% eradication

Allicin (1200 mcg) – 23.3% eradication

The authors noted that ascorbic acid and beta-carotene were ineffective whereas allicin was effective in enhancing traditional treatment and also modestly effective by itself.

It’s worth noting that the dose on the allicin-only group was lower, so it’d be interesting to see if a higher dose was more effective. [2]

Taking garlic supplements which contain stabilized allicin will likely be more effective than consuming raw garlic. But a more recent study from 2016 suggests that just eating two medium-sized cloves of garlic (noon and evening) can have a meaningful antibacterial effect on h.pylori in the stomach. [3]

Manuka Honey

Money honey was the turning point for me when I had gastritis. After having issues with feeling bloated all the time, stomach pressure and pain, and even GERD, honey was the first thing that ever made a difference.

Within days (yes, days!!) most of my stomach symptoms were gone. In just two weeks it felt like the infection had been completely eradicated. But the problem came back after two or three months and I started having the same symptoms.

This time, instead of stopping after just two weeks, I continued to put manuka honey on my toast every morning for breakfast, and also midday and in the evening before I went to bed. This way the honey was able to remain in the stomach for longer to have an effect.

I continued doing this for months if not years on and off and the symptoms never returned. They still haven’t to this day and it’s been over 11 years.

Considering that I had this problem for over at the time, and my doctor had no answer for me, it was pretty amazing that something as simple as manuka honey could cure this problem I was having.

But is there any evidence for it?

Absolutely. In a study looking at the effect of manuka honey on H.pylori growth, they were able to show that the presence of Manuka Honey at just 5% of its full strength was able to completely inhibit the growth of the bacteria. [4]

They estimated that the dose which would be required to have an antibacterial effect would be around 2.5 ml of honey entering 50 ml or less of gastric fluid before a meal.

This is the brand of manuka honey I used to help cure the infection.

If you’re going to try it, make sure that you use manuka honey, not just regular honey.

Probiotics

Taking probiotics before, during and after treatment with antibiotics for H pylori may help improve eradication rates according to a few studies done in humans.

In one study published in the American Journal of Clinical Nutrition, 138 patients who had failed triple-therapy were enrolled into a study and half of them given Lactobacillus and Bifidobacterium-containing yogurt for 4 weeks prior to treatment.

In the study, they saw that probiotics were able to increase the eradication rate of H.pylori in infected patients to 85% compared to 71% of patients in the quadruple therapy alone.

In another study that used probiotics after treatment, they showed that the eradication rate increased from 60.8% to 79.2%. The researchers believed that the probiotic bacteria may have inhibited any residual bacteria left over after treatment. [5]

The benefit of taking probiotics also is that if you opt for antibiotic treatment, the probiotics will help keep in check harmful bacteria and yeast that will have an opportunity to grow during the antibiotic treatment.

Green Tea

Green tea contains polyphenols which have some antibacterial effect and help quell inflammation in the stomach. In this study, green tea had a bacteriostatic and bacteriocidal effect on both H. felis and H. pylori bacteria.

Green tea may be a good preventative for both preventing infection and also reducing inflammation of the stomach if consumed before exposure to H. pylori.

If you’re going to go try and include green tea into your regimen, make sure you get the teas with the highest levels of EGCG. You can find out more information about the difference between matcha and sencha here.

Licorice Tea

Licorice may have a place for patients looking for an alternative to the medication Bismuth (antacid) because of side effects.

Patients taking the standard quadruple protocol to eradicate H.Pylori which includes bismuth were compared against another group of patients using licorice in its place.

The study used 380 mg of licorice, twice a day and found that it was as effective as bismuth, based on outcomes such as gastritis, gastric ulcers, duodenitis and duodenal ulcers.

Licorice not only has an antibacterial effect against H.pylori but it also helps stop the bacteria from sticking to the walls of the stomach. [6]

Resveratrol

Resveratrol is found in grapes and red wine, but getting enough of this compound can be difficult unless you supplement it.

It’s powerful antioxidant effects and antibacterial properties make it useful in helping inhibit gastric inflammation and also inhibiting the growth of the bacteria at concentrations between 6.25 – 25 mcg/mL. [7]

Olive Oil

Test tube studies showed that olive oil was effective at killing Helicobacter pylori, and that olive oil was stable in the stomach acid so it could be beneficial.

So researchers created two studies to evaluate its effectiveness in patients.

In one study, 30 patients who had been tested positive for the infection was to receive 30 grams of olive oil for 14 days.

Around 24-72 hours after the last dose of washed virgin olive oil, 12 of the 30 patients showed a negative result. However, after 4-6 weeks, only 8 of the 30 still had a negative result.

In the second clinical intervention, only 3 of the 30 were negative after 4-6 weeks, but 24-72 hours after the last dose of unwashed virgin olive oil, 5 of the 30 tested negative. [8] Thirteen of the patients had to withdraw due to the taste and nausea from the oil.

Although olive oil didn’t provide a complete cure and many patients ended up tested positive again, olive oil can be consumed safely every day and is very beneficial to health.

So your results may be better with continued use of polyphenol-rich extra virgin olive oil.

Turmeric and Ginger

Both come from the same family and have shown (in vitro) to have significant antibacterial effects against different strains of H. Pylori.

While turmeric has powerful anti-inflammatory effects due to its high curcumin content, ginger acts as an anti-emetic and may, therefore, increase appetite.

Anti-H.Pylori Diet

Many of these ingredients are easy to find and can be used in everyday foods and drinks! One drink I would often make was the following:

  • Green tea (Sencha or matcha)
  • Ginger powder – 1 teaspoon
  • Turmeric powder – 1 teaspoon
  • Manuka Honey – 1 tablespoon

If you make some toast you can use a tablespoon of extra virgin olive oil and then take 5 – 10 allicin capsules (180 mg each) and then pour them on top of the bread. Add a banana on top and this will help keep the ingredients in the stomach long enough to have an effect (or skip the banana if you wish!)

Foods to avoid

While you’re trying to heal from the infection, it’s best not to start irritating your stomach put eating foods which can worsen gastritis.

  • Salt
  • Simple carbohydrates
  • Picked foods
  • Alcohol
  • High caffeine beverages
  • acidic foods (tomatoes, citrus fruits)
  • Chocolate

Conclusion

H. Pylori infections can be really uncomfortable and withstand some of the strongest antibiotics we have today.

Fortunately, nature has provided us with tools which can effectiveness by themselves and complement traditional therapies using antibiotics.

Most of these natural treatments are just regular food items that are often found in the kitchen or local supermarket! If we can get away with using less antibiotics, then that’s a good thing!

How To Gain Weight on a Vegan Diet

A raw vegan diet is one of the best ways to lose weight, but this shouldn’t be everyone’s goal. If you’re starting the diet and you’re already quite skinny, chances are you’re going to end up even skinnier if you don’t make some adjustments. If your goal is to gain weight on a vegan diet, you should try to do it in a healthy way rather than going for the junk food.

Jared Leto is one famous vegan who once gained an amazing amount of weight for a film role, but he did it in a very unhealthy way. Perhaps time wasn’t on his side because of his schedule and filming, but you have time, so you should make sure that you eat the right foods so that you put on a healthy percentage of muscle and fat.

Gaining weight is usually as simple as just choosing the right foods. Although genetics does play a role, and sometimes a person can have defiecncies and food intolerances which makes it more difficult.

Being underweight and being overweight can have their own unique risks, so it’s important to reach a weight where you feel healthy and you are happy with how you look.

Risks of having a low body weight

Although I practice a calorie restriction diet, I’m fully aware of the risks of maintaining a low body weight. When you have a low body weight it’s crucial that you maintain your body with excellent nutrition and are cautious about the dangers. You really should aim to find a balance. Yes, lean is healthy, but there can be some symptoms associated with it if your weight drops too much.

  • Orthostatic hypotension – This symptom often appears when you’re sitting down and then you suddenly get up off the chair and feel dizzy.
  • Hormonal imbalance – Women can have menstrual cycle irregularities and loss of their period.
  • Reduced bone density – You may be at greater risk of osteoporosis if you maintain a low body weight and are not actively training to strengthen and maintain bone mass.
  • Sleep disturbances – If an animal goes without food for too long, it will have significantly reduced sleep. The same appears to be true for humans. People who restrict calories significantly and have a very low body weight have difficulty staying asleep for a full 8 hours.
  • Poor immune function – One of the biggest risks for someone who maintains a low body weight is overcoming serious infections.
  • Poor wound healing – Low-calorie intake and body weight may lead to slower wound healing until calorie intake is increased.
  • Heart problems – Losing weight fast or losing an extreme amount of weight can lead to arrhythmias.
  • Always feeling cold – It’s common for people to start feeling really cold as they decrease calorie intake. If you live in a cold climate, this could become a problem.
  • Medication reactions – Having a low body weight might make you more susceptible to the side effects of medication.
  • Social pressures – Concern from friends and family may cause anxiety and other issues which can affect your health.

It’s very possible to maintain a low body weight, be healthy and manage the risks, but it’s worth acknowledging a few of the drawbacks that you can encounter.

There are usually a few reasons why someone wants to gain weight on a vegan diet

  • Looking to gain an athletic and healthy physique
  • Training to become a bodybuilder
  • Their weight has dropped too low after starting a vegan diet and it was unintentional
  • Pressure from friends and family about how thin they look (this is common, even if you are at a healthy weight. People just aren’t used to it).
  • Eating disorders
  • Health conditions which make it risky to maintain a low body weight

Most of the time extreme weight loss on a vegan diet will be unintentional. A vegan diet is a really effective way to lose weight.  But whatever the reason, the main thing you should aim for is to be happy and healthy.

How to gain weight without losing your health

When you start trying to gain weight, you might feel quite bloated as you adjust to the amount of food you have to eat to be in caloric surplus, but these feelings can be reduced by changing some of the foods you eat.

Over time your body will adapt, stomach grows, and you’ll start to feel more comfortable with the number of meals and portion sizes you need to eat.

Many studies show that vegans are the skinniest of the bunch. Skinnier than vegetarians, omnivores, and those on a carnivorous diet. But it’s not impossible to gain weight if you want.

I recommend you also check out my article on how to start a vegan diet for some extra tips and ideas for foods to eat.

1. Eat more food and increase calories

I know, I’m stating the obvious. But there’s no getting around the fact that you need consume more food which is more calorically dense and also increase the number of meals you’re having each day.

So if you normally have two meals during the day, consider having 3 big meals and one or two snacks in between them.

Choose foods which really increase your caloric intake without making you feel too full. These would be foods like sweet potatoes, olive oil, avocado, beans, vegan vegetable burgers, soy milk etc. You can also consume healthy treats like dry fruit, or have some chocolate, which is high in fat and has a lot of calories per serving.

Drinking smoothies or meal replacement shakes are also another excellent way of getting lots of plant-based nutrition and increasing your calorie intake. These can be especially useful if you’re quite busy and find yourself missing meals often. Protein bars can be another option for you.

Check out some more ideas here on how to increase calorie intake.

Also, don’t forget to check out how many calories you’re actually eating by using a tool to track it. That would be a great starting point so you can tell how many calories you need to aim for each day to gain weight at a steady pace.

2. Change your macronutrient balance

Use a programme like CRON-O-METER to check out the percentage of carbohydrates, fats, and protein you’re consuming.

I found that eating a lot of carbohydrates made it difficult to gain weight. The way I saw better gains was to increase the number of healthy fats in my diet from nuts, seeds, avocado and olive oil.

Protein powders were also very helpful too. Find out more about the benefits of drinking protein shakes on a vegan diet.

All three macronutrients are important in the diet and each serves a purpose, but plant-foods tend to be really high in water, low in calories and can get you feeling full fast. This will make it much harder to consume the amount of food you need to gain the weight.

Fat, on the other hand, has 9 k/calories per gram and can be added to many different meals easily. Even if you were to have a piece of wholemeal bread, you can put a tablespoon of extra virgin olive oil on there and a banana. Simple and fast!

If your fat intake comprises of around 10% of your diet right now, consider raising that to 20-30% and raise your protein intake to 15%. The rest will come from calorically dense carbohydrates. But of course, don’t forget the greens! I’m not saying don’t eat them, but don’t make a gigantic salad with them which takes you an hour to eat.

3. Smoothies are easy calories

Although I’m not a big green smoothie drinker as I used to be (I prefer to have whole meals), I still drink them a few times a week. During my weight gain phase, they were great because I could get in a lot of calories and not feel extremely full doing so.

You can throw so many different foods into a smoothie and usually, it comes out tasting great. Usually. 😉

Well, there’s been a few times where the smoothie has gone to waste because of bad food combinations, but there are plenty of ideas out there for some tasty smoothies.

Throw in some fruits like mangos, pineapple, avocado, bananas, flaxseeds, vegan protein powder, almond milk (or other vegan milk) with about 30% greens like baby spinach and you’re good! Oh and the water… Don’t forget that.

4. Add in healthy snacks

It’s movie time and you’re ready to sit down to enjoy. Why not get some snacks in during this time? It could be some grapes, mixed nuts, dried fruit, vegan muffins or vegan yogurt.

We tend to eat more when we’re not paying attention. Whether it be watching TV or being at the computer.

5. Less running more weights

If you’re doing intense cardio workouts, why not change that up for some walks, gardening and other activities which don’t burn up a lot of calories?

Go to the gym and start lifting weights to build up muscle. This will help improve your confidence, muscle tone, balance, posture, reduce the risk of osteoporosis. It will also improve your mood and help reduce glucose levels by increasing insulin sensitivity.

Consider doing some yoga as well. It’s a low impact and low calorie and amazing for your health.

Maybe even get a trainer if you can afford it. They will be able to shape your body in the way you want.

 6. Don’t rush it

Crash dieting is not a good idea and neither is rapid weight gain. Any shock to the system is not good and can lead to long-term health complications down the line.

If you’re just gaining a pound a week, then that’s fantastic, you don’t really need to gain faster than that. This isn’t a race, but you’re trying to get yourself in the best shape possible.

Of course, if you’re competing competitively in a sport then that’s a different story. You’re likely going to see bigger gains from the hard training and change in diet. But for the average person who has a pretty normal lifestyle, go slow and steady.

What you should not do

I’ve seen many different diets come and go over the last 15 years, and the ones I am certainly not a fan of are these mono-food diets. 30 bananas a day comes to mind. I simply do not think this is healthy and you’re missing out on a whole range of phytonutrients, not to mention a large amount of sugar you’re getting from the fruit.

  • Don’t eat 30 of anything a day whether it be mangos, bananas, dates or whatever. It’s not healthy in the long term.
  • Don’t eat until the point where you feel like you’re going to be sick.
  • Don’t rush while you eat. You want to digest the food well so you can absorb the nutrients.
  • Don’t rely on vegan cookies or any vegan junk food. They can be good for a treat every now and then, but should only be a small part of the diet.
  • Don’t add white sugar to your smoothies (I’ve seen vegans do this), and avoid high sugar drinks that have no nutritional value. Drink water or tea.

My own experience gaining weight healthily

Last I just want to share my story about my own weight gain.

I’ve been eating a largely raw food, plant-based diet now for over 15 years and there was a time when I was really skinny. These days my body is more athletic and lean and I never get any comments about being too skinny.

Ten years ago I was at my lowest BMI ever, it was around 16.3. Yeah, I know, crazy right? It was intentional because I had been practicing calorie restriction in order to slow down aging. I restricted my calorie intake to around 1550 k/cal per day and this is where my BMI dropped to before things started to stabilize.

According to blood work and other measurements of health, I was super healthy. But obviously, I never looked that way due to my low body weight.

I also felt that it was quite risky to maintain such a low body weight, so at some point, I decided to increase my calorie intake and raise my BMI to where I felt I looked healthier and was able to still maintain very good biomarkers (glucose, cholesterol, inflammation markers etc.)

When you’re at such a low weight, it can be quite difficult to gain it back, at least at first. I had to change the foods I was eating to include more calorically-dense foods and also cut back a bit on cardio workouts and start lifting weights instead to build muscle mass.

When you’re trying to gain weight, you’ don’t want to just pile on pounds of fat without increasing muscle mass. This will ensure that you have good insulin sensitivity and low glucose levels.

So anyway, I gained around 15 lbs and that put me around a BMI of 19.5, which falls within the healthy BMI range.

It’s still quite lean, but it still fits in with my practice of CR. For my body frame, this appears to be more healthy for me, but for someone with a larger frame, it might still look too skinny.

I gained this weight in just over three months. Which sounds like a lot of time for such a small amount of weight, but much of this was muscle.

In recent years my metabolism appears to have slowed down a lot, and now I’m able to maintain a BMI of 19.5 with a calorie intake of around 1600 k/cal per day. This works out perfectly for me!

Conclusion

A vegan diet can lead to significant weight loss which can be concerning if you already have a low body weight. But usually there is nothing wrong, but calorie intake has dropped a lot and you’re not making up for it by choosing foods which are high in calories.

This is pretty common in the raw food community, but once you understand ab it about nutrition and which foods to eat, it’s easy to maintain a healthy a susutainable weight on a vegan diet.

AHCC Supplement Health Benefits and Side Effects

Active Hexose Correlated Compound or AHCC for short is a supplement that’s used primarily in Asia, usually as a complementary treatment for serious diseases like cancer. When used in combination with chemotherapy it can enhance the treatment and protect against side effects.

AHCC is derived from an extract of hybridized Basidiomycetes, which includes a popular mushroom known as Shiitake. This unique species with a blend of alpha and beta glucan provide significant antioxidant benefits as well as enhance immune responses to disease.

I’ve used AHCC supplements many times in the past. It’s quite expensive compared to the standard beta glucan supplements you’ll find in the store, but it’s worth having around in case you develop an infection.

AHCC was one of the main supplements I used in combination with antibiotics to treat a difficult-to-treat bacterial infection I had around 10 years ago. It seemed quite effective in helping reduce inflammation and symptoms of infection, and I believe contributed to me being able to cure it.

Benefits of AHCC

There are numerous benefits of AHCC, so in this article, I’ll take a look at some of the latest research and findings from clinical trials and studies. Immunotherapy in cancer research has been a hot area for the last few years, and AHCC may be one good natural supplement to take to enhance immunity.

Boosts Immune System

Our innate and adaptive immune system are both crucial in keeping us alive. Over time, the immune system can become weak due to nutrient deficiencies, lack of sleep, chronic infections and aging. As you get older it becomes harder to fight off infections that your immune system could simply shrug off.

Natural compounds food supplements like AHCC has been shown to boost various parts of the immune which are important for fighting off bacterial, viral, and fungal infections.

The innate part of the immune system is the most primitive and acts almost immediately in response to invaders. And if it’s not defeated in time, the adaptive immune system starts going into high-gear producing antibodies by T cells and B cells.

In a double-blind, placebo-controlled study, researchers looked at the immunological effects of AHCC on various immune system parameters.

Healthy volunteers who were given AHCC at 3.0 grams per day for 4 weeks were studied to see the effect of AHCC on immune cells. The study found that AHCC group had a significantly higher number of dendric cells

Dendric cells help initiate T cell response and are important for innate and adaptive immune system communication.

AHCC effect on the Innate Immune System

  • Increases the production of various pro-inflammatory cytokines and anti-inflammatory cytokines to attract immune cells and regulate the immune response
  • Increases the number of Natural Killer cells by up to 800% in clinical trials
  • Can double the number of macrophages which engulfs foreign invaders and debris from the fallout
  • Increases the number of dendric cells in the body which help initiate the response by B cells and T cells

AHCC effect on the adaptive immune system

  • Clinical trials on humans have shown that AHCC can increase T cells by up to 200% in healthy adults
  • Continued benefit for at least 30 days after stopping AHCC on T4 helper cells and T8 suppressor/killer cells

Bacterial infections

Over the last few decades, antibiotic use has increased and as a consequence, the world is heading towards crises with super resistance bacteria which may make the antibiotics we use and depend on completely useless.

Using natural compounds like AHCC and other beta glucans to prevent and enhance the effectiveness of antibiotics has been studied and show some remarkable synergistic effects.

Most of the research done so far appears to be using beta-glucans, but AHCC has similar or more potent effects due to its high amount of alpha-glucans.

In a study published in 2008 in the American Journal of Surgery, researches looked at the effect of AHCC on post-surgical wound infection in mice.

The AHCC group had significantly reduced bacterial load by day 5 and cleared the bacterial infection entirely by day 6 of the treatment. The AHCC group appeared to have a more robust and rapid immune response with levels of IL-12, TNF-a, and IL-6 peaking at day 3 compared to day 6 for the control group.

As reported in earlier studies, AHCC was able to increase levels of lymphocytes and monocytes, thus leading to increased number of macrophages to clear the infection. [2-3].

In a study not on AHCC, but using PGC-Beta glucan (beta glucan are also found in AHCC), researchers found that supplementing patients who underwent high-risk gastrointestinal surgery was able to reduce serious post-operative infections or death by 39%. [4].

There are many other studies which show similar results in being able to significantly reduce death from many types of bacterial infections, even anthrax-infected mice.

Where survival was increased from 30% to 90% after they were given beta-glucan 10 days post-infection. If they were given beta glucan before the infection, they had 100% survival [5].

Combining AHCC or beta glucans could be an effective strategy to use with antibiotics to increase their effectiveness.

Viral infections

There is a lot more research on AHCC and viral infections and immune compared to bacterial infections. If you could take something which would prevent the common cold or flu, AHCC might be a good candidate according to research.

Even when AHCC is given at low doses, it is able to help improve immune system response to influenza infection. This is without any increase in Natural Killer cell cytotoxicity [6].

Another study published in 2006 showed that mice given AHCC had improved survival compared to controls and reduces the severity of influenza infection in the young mice. Natural Killer cell activity was also significantly enhanced.

Other studies have shown that AHCC to improve outcomes and survival for avian flu as well.

Improved antibody response to influenza B vaccine

In a randomized controlled study, 30 healthy adults were given 3 grams of AHCC per day, immediately after the injection. The study had one treatment and one group.

In the subjects given the AHCC were shown to have increased Natural Killer T Cells and CD8 T cells post-vaccination. Antibodies were measured at 3 weeks post-vaccination and the AHCC also showed significantly improved antibody production, while the improvement in the control group was not significant [7].

Antibody response to vaccines can vary depending on age, nutrition, and other factors. AHCC might be able to make vaccines more effective in healthy patients and those who don’t respond well.

AHCC improves T cell immune response in healthy adults

In another study published in 2010, AHCC was given to healthy adults who were at least 50 years old. The study found that AHCC was able to significantly enhance CD4 and CD8 T cell immune responses and the effect persisted even after they discounted the supplement for 30 days.

AHCC could an effective way to boost resistance to viral infections in the elderly and those who have a compromised immune system.

AHCC cures HPV infection in Women

In 2014 some amazing results came out of a small clinical trial on using AHCC to treat HPV-positive women. In short, the study was very successful. After six months of being given AHCC, five of the patients received a negative HPV test result and three confirmed eradication of the virus after stopping the supplement.

The remaining responders to the supplement continued on with the study to complete it.

HPV is associated with over 99% of cervical cancer cases in women but is also responsible for several other cancers as well.

Since the study showed an overwhelmingly positive result, they immediately set up a Phase II randomized, placebo-controlled trial at Houston Medical School.

Cancer

Over at AHCC Research, there are many studies available to read on AHCC being used to treat cancer and also reduce side effects from chemotherapy.

Two types of cancer that AHCC appears to be very effective at improving survival are gastric cancer and colon cancer.

In a study between 1995 – 2002, 245 patients were recruited into the study to use AHCC in combination with standard treatment using chemotherapy.

Patients who had stage 1-3 gastric or colon cancer were given 3.0 grams per day of AHCC, while Stage IV patients were given 6.0 grams a day (3 times daily).

Compared to the 5 Year Survival by Japanese gastric cancer associated and other Japanese Institutions, the 5-year survival study which included AHCC as part of the standard treatment protocol did much better.

Gastric cancer survival rates (AHCC vs Standard treatment)

Stage 5 Year Survival (AHCC) Standard Treatment
Japanese Gastric Association
Standard Treatment
Other Japanese Institutions
Stage IA 100% 93.4% 91.5 – 93.4% Survival
Stage IB 100% 87.0% 85.5 – 88.7%
Stage II 92.3% 68.3% 74.9 – 75.9%
Stage IIIA 82.8% 50.1% 53.6 – 61.7%
Stage IIB 35.7% 30.8% 40.4% – 42.4%
Stage IV 14.3% 16.6% Stage IVA – 14.3 – 19.7%
Stage IVB – 4%

Colon cancer survival rates (AHCC vs Standard treatment)

Stage 5 Year Survival (AHCC) 5 Year Survival
Other Japanese Institutions
Stage 0 100% 100%
Stage I 100% 93 -100%
Stage II 100% 81 – 88%
Stage IIIA 95.2% 73 – 76%
Stage IIIB 73.3% 63 – 78%
Stage IV 7.1% 0 – 17%

As you can see from these tables, AHCC in combination with chemotherapy significantly enhances survival of patients with stomach cancer and colon cancer. You can see more details from this paper here.

More recent studies have found that AHCC is also helpful for people who have unresectable pancreatic cancer.

Patients given 6.0 grams of AHCC for 2 months were found to have improved biomarkers (CRP and albumin), as less grade 3 Glasgow prognostic score during chemotherapy int he AHCC group (14% compared to 53% in the controls) [8].

Side effects

AHCC has a good safety record and has bees shown to be safe with minimal side effects at currently recommended doses. Side effects usually low with no major changes in blood work.

In 2007, a phase I clinical trial involving healthy volunteers were given AHCC for 14 days. 26 healthy males and females between the age of 18 and 61 were in the study.

Each was given 9 grams of AHCC per day (liquid form) and then monitored for side effects.

Two subjects (7%) experienced nausea from consuming the liquid. Some patients reported transient adverse reactions such as cramps, headache, diarrhea, and general fatigue, but these only occured in 6 subjects. They concluded that 85% of the subjects were able to tolerate the supplement at a high dose (9 grams).

Most studies involve patients taking AHCC between 3 – 6 grams per day. For maintaining a healthy immune system and maintenance dose, this can be as low as 500-750 mg per day, which should result in fewer side effects.

References

1. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Nutr Cancer. 2008;60(5):643-51. doi: 10.1080/01635580801993280.

2. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults. Hum Immunol. 2010 Dec;71(12):1187-90. doi: 10.1016/j.humimm.2010.08.006. Epub 2010 Aug 21.

3. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008 Apr;195(4):537-45. doi: 10.1016/j.amjsurg.2007.05.045.

4. Effect of PGG-glucan on the Rate of Serious Postoperative Infection or Death Observed After High-Risk Gastrointestinal Operations. Arch Surg. 1999;134(9):977-983. doi:10.1001/archsurg.134.9.977

5. Anthrax-protective effects of yeast beta 1,3 glucans. MedGenMed. 2003 Mar 21;5(1):1.

6. Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice. Nutr Res. 2009 Feb;29(2):139-43. doi: 10.1016/j.nutres.2009.01.005.

7. Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. 2013 Jan;33(1):12-7. doi: 10.1016/j.nutres.2012.11.001. Epub 2012 Dec 4.

8. Alleviating Effect of Active Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients with Unresectable Pancreatic Ductal Adenocarcinoma. Nutr Cancer. 2016;68(2):234-40. doi: 10.1080/01635581.2016.1134597. Epub 2016 Feb 4.

9. A phase I study of the safety of the nutritional supplements, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol (Tokyo). 2007;53:536-539.